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Glucosamine

What is osteoarthritis?
An estimated 21 million adults in the United States live with osteoarthritis--one of the most common types of arthritis. Osteoarthritis, also called degenerative joint disease, is caused by the breakdown of cartilage, which is the connective tissue that cushions the ends of bones within the joint. It is characterized by pain, joint damage, and limited motion. The disease generally occurs late in life, and most commonly affects the hands and large weight-bearing joints. Although the disease can impact several joints, the knees are often affected. Age, female gender, and obesity are risk factors for this condition.

What are glucosamine and chondroitin?
Glucosamine and chondroitin are natural substances found in and around the cells of cartilage. Researchers believe these substances may help in the repair and maintenance of cartilage. In addition, researchers believe that glucosamine inhibits inflammation and stimulates cartilage cell growth, while chondroitin provides cartilage with strength and resilience. Currently, glucosamine and chondroitin are classified as dietary supplements.

What is a dietary supplement?
A dietary supplement is a product (other than tobacco) intended to supplement the diet, which bears or contains one or more of the following dietary ingredients: a vitamin, mineral, amino acid, herb, or other botanical; is intended for ingestion in the form of a capsule, powder, softgel, or gelcap; and is not represented as a conventional food or as a sole item of a meal or the diet (as defined by the U.S. Dietary Supplement Health and Education Act, Oct. 25, 1994).

What is celecoxib?
Celecoxib (brand name Celebrex) is a new type of nonsteroidal anti-inflammatory drug (NSAID), called a COX-2 inhibitor. Like traditional NSAIDS, celecoxib blocks the COX-2 enzyme in the body that stimulates inflammation. Unlike traditional NSAIDS, however, celecoxib does not block the action of COX-1 enzyme, which is known to protect the stomach lining. As a result, celecoxib reduces joint pain and inflammation with reduced risk of gastrointestinal ulceration and bleeding.

For More Information

NCCAM Clearinghouse
Toll-free in the U.S.: 1-888-644-6226
International: 301-519-3153
TTY (for deaf and hard-of-hearing callers): 1-866-464-3615

E-mail: info@nccam.nih.gov
Web site: nccam.nih.gov
Address: NCCAM Clearinghouse, P.O. Box 7923, Gaithersburg, MD 20898-7923

Fax: 1-866-464-3616
Fax-on-Demand service: 1-866-644-6226

The NCCAM Clearinghouse provides information about CAM and about NCCAM.

For information on rheumatic diseases such as osteoarthritis and diseases of the musculoskeletal and skin systems, contact the National Institute of Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse by mail at NIAMS/National Institutes of Health, 1 AMS Circle, Bethesda, Maryland 20892-3675, by phone at 301-495-4484, or at its Web site.

For information on dietary supplement labeling requirements and safety monitoring, order the FDA Guide to Dietary Supplements from the U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition at 800-FDA-4010, or visit its Web site.

For scientific citations and abstracts on dietary supplements, visit the NIH Office of Dietary Supplements (ODS) Web site for access to the International Bibliographic Information on Dietary Supplements database. This database is maintained through an interagency partnership between the ODS and the U.S. Department of Agriculture, National Agricultural Library, Food and Nutrition Information Center.

Tendintis information and treatment options

 
     
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