What is Cancell/Entelev?
Cancell/Entelev, also known as Sheridan’s Formula, Jim’s Juice, Crocinic Acid, JS–114, JS–101, 126–F, and Cantron, is a liquid that has been distributed as a treatment for cancer and a wide range of other diseases. Cancell/Entelev has been produced in various forms, principally by two manufacturers, since the late 1930s.
The U.S. Food and Drug Administration (FDA) has listed the components of Cancell/Entelev as the chemicals inositol, nitric acid, sodium sulfite, potassium hydroxide, sulfuric acid, and catechol. However, the exact composition of Cancell/Entelev is unknown. Independent tests on one form of Cancell/Entelev found 12 different compounds, none of which are known to be effective in treating any form of cancer.
What is the history of the discovery and use of Cancell/Entelev as a complementary or alternative treatment for cancer?
The two principal manufacturers of Cancell/Entelev have offered different explanations for the development of cancer, but their theories about how the mixture works against cancer are similar. According to the original manufacturer, Cancell/Entelev changes cancer cells so they are seen by the body as “foreign” and are destroyed. The second manufacturer states that Cancell/Entelev changes cancer cells so they “self-digest” and are replaced by normal cells. The waste material produced by this self-digestion process is eliminated through urine, perspiration, and other body fluids.
How is Cancell/Entelev administered?
Have any side effects or risks been reported from Cancell/Entelev?
Have any preclinical (laboratory and animal) studies been conducted using Cancell/Entelev?
The principal manufacturers of Cancell/Entelev have stated that they have performed many animal experiments with the mixture. None of these studies have been published in peer-reviewed, scientific journals. No information has been provided, beyond stating that some of the experiments tested the toxicity (undesirable and harmful side effects) of Cancell/Entelev.
Have any clinical trials (research studies in humans) been conducted with Cancell/Entelev?
Has the Food and Drug Administration (FDA) approved Cancell/Entelev for use in the United States?
When considering complementary and alternative therapies, what questions should patients ask their health care provider?
What benefits can be expected from this therapy?
How are complementary and alternative approaches evaluated?
More information about how CAM approaches are evaluated can be found in the National Cancer Institute (NCI) fact sheet Complementary and Alternative Medicine in Cancer Treatment: Questions and Answers. This fact sheet can be accessed at http://cis.nci.nih.gov/fact/9_14.htm on the Internet, or by calling the Cancer Information Service (CIS) at 1–800–422–6237.
How can patients and their health care providers learn more about complementary and alternative therapies?
The NIH National Center for Complementary and Alternative Medicine (NCCAM) facilitates research and evaluation of complementary and alternative practices, and provides information about a variety of approaches to health professionals and the public.
NCCAM and the NIH National Library of Medicine (NLM) jointly developed CAM on PubMed, a free and easy–to–use search tool for finding CAM–related journal citations. As a subset of the NLM's PubMed bibliographic database, CAM on PubMed features more than 230,000 references and abstracts for CAM–related articles from scientific journals. This database also provides links to the Web sites of over 1,800 journals, allowing users to view articles in full–text. (A subscription or other fee may be required to access full–text articles.) CAM on PubMed is available through the NCCAM Web site at http://nccam.nih.gov. It can also be accessed at http://www.ncbi.nlm.nih.gov/PubMed by selecting "Limits" and choosing "Complementary Medicine" as a subset.
The NCI Office of Cancer Complementary and Alternative Medicine (OCCAM) coordinates the activities of the NCI in the area of complementary and alternative medicine (CAM). OCCAM supports CAM cancer research and provides information about cancer–related CAM to health providers and the general public via its Web site http://www.cancer.gov/cam on the Internet.
The Food and Drug Administration (FDA) regulates drugs and medical devices to ensure that they are safe and effective.
Food and Drug Administration
The Federal Trade Commission (FTC) enforces consumer protection laws. Publications available from the FTC include:
"Who Cares: Sources of Information About Health Care Products and Services"