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Magnesium
When can magnesium deficiency occur?
Even though dietary surveys suggest that many Americans do not consume magnesium in recommended amounts, magnesium deficiency is rarely seen in the United States in adults. When magnesium deficiency does occur, it is usually due to excessive loss of magnesium in urine, gastrointestinal system disorders that cause a loss of magnesium or limit magnesium absorption, or a chronically low intake of magnesium .
Treatment with diuretics (water pills), some antibiotics, and some medicine used to treat cancer, such as Cisplatin, can increase the loss of magnesium in urine (4, 10). Poorly controlled diabetes increases loss of magnesium in urine, causing a depletion of magnesium stores (6). Alcohol also increases excretion of magnesium in urine, and a high alcohol intake has been associated with magnesium deficiency (11, 12).
Gastrointestinal problems, such as malabsorption disorders, can cause magnesium depletion by preventing the body from using the magnesium in food. Chronic or excessive vomiting and diarrhea may also result in magnesium depletion .
Signs of magnesium deficiency include confusion, disorientation, loss of appetite, depression, muscle contractions and cramps, tingling, numbness, abnormal heart rhythms, coronary spasm, and seizures .
Who may need extra magnesium?
Healthy adults who eat a varied diet do not generally need to take a magnesium supplement. Magnesium supplementation is usually indicated when a specific health problem or condition causes an excessive loss of magnesium or limits magnesium absorption (2, 6, 7, 11-16).
Extra magnesium may be required by individuals with conditions that cause excessive urinary loss of magnesium, chronic malabsorption, severe diarrhea and steatorrhea, and chronic or severe vomiting.
Loop and thiazide diuretics, such as Lasix, Bumex, Edecrin, and Hydrochlorothiazide, can increase loss of magnesium in urine (7). Medicines such as Cisplatin (10), which is widely used to treat cancer, and the antibiotics Gentamicin, Amphotericin, and Cyclosporin also cause the kidneys to excrete (lose) more magnesium in urine (6). Doctors routinely monitor magnesium levels of individuals who take these medicines and prescribe magnesium supplements if indicated.
Poorly controlled diabetes increases loss of magnesium in urine and may increase an individual's need for magnesium. A medical doctor would determine the need for extra magnesium in this situation. Routine supplementation with magnesium is not indicated for individuals with well-controlled diabetes (14, 15, 17, 18).
People who abuse alcohol are at high risk for magnesium deficiency because alcohol increases urinary excretion of magnesium. Low blood levels of magnesium occur in 30 percent to 60 percent of alcoholics, and in nearly 90 percent of patients experiencing alcohol withdrawal (12). In addition, alcoholics who substitute alcohol for food will usually have lower magnesium intakes (11, 12). Medical doctors routinely evaluate the need for extra magnesium in this population.
The loss of magnesium through diarrhea and fat malabsorption usually occurs after intestinal surgery or infection, but it can occur with chronic malabsorptive problems such as Crohn's disease, gluten sensitive enteropathy, and regional enteritis (13). Individuals with these conditions may need extra magnesium. The most common symptom of fat malabsorption, or steatorrhea, is passing greasy, offensive-smelling stools.
Occasional vomiting should not cause an excessive loss of magnesium, but conditions that cause frequent or severe vomiting may result in a loss of magnesium large enough to require supplementation. In these situations, your medical doctor would determine the need for a magnesium supplement.
Individuals with chronically low blood levels of potassium and calcium may have an underlying problem with magnesium deficiency. Adding magnesium supplements to their diets may make potassium and calcium supplementation more effective for them (2, 16). Doctors routinely evaluate magnesium status when potassium and calcium levels are abnormal, and prescribe a magnesium supplement when indicated.
What is the best way to get extra magnesium?
Doctors will measure blood levels of magnesium whenever a magnesium deficiency is suspected. When levels are mildly depleted, increasing dietary intake of magnesium can help restore blood levels to normal. Eating at least five servings of fruits and vegetables daily, and choosing dark-green leafy vegetables often, as recommended by the Dietary Guidelines for Americans, the Food Guide Pyramid, and the Five-a-Day program, will help adults at-risk of having a magnesium deficiency consume recommended amounts of magnesium. When blood levels of magnesium are very low, an intravenous drip (IV drip) may be needed to return levels to normal. Magnesium tablets also may be prescribed, but some forms, in particular magnesium salts, can cause diarrhea (19). Your medical doctor or qualified health-care provider can recommend the best way to get extra magnesium when it is needed.
What are some current issues and controversies about magnesium?
Magnesium and blood pressure
Evidence suggests that magnesium may play an important role in regulating blood pressure (4). Diets that provide plenty of fruits and vegetables, which are good sources of potassium and magnesium, are consistently associated with lower blood pressure (20-22). The DASH study (Dietary Approaches to Stop Hypertension) suggested that high blood pressure could be significantly lowered by a diet high in magnesium, potassium, and calcium, and low in sodium and fat (23-26). In another study, the effect of various nutritional factors on incidence of high blood pressure was examined in over 30,000 U.S. male health professionals. After four years of follow-up, it was found that a greater magnesium intake was significantly associated with a lower risk of hypertension (27). The evidence is strong enough that the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure recommends maintaining an adequate magnesium intake as a positive lifestyle modification for preventing and managing high blood pressure (28-30).
Magnesium and heart disease
Magnesium deficiency can cause metabolic changes that may contribute to heart attacks and strokes (31-33). There is also evidence that low body stores of magnesium increase the risk of abnormal heart rhythms (4), which may increase the risk of complications associated with a heart attack. Population surveys have associated higher blood levels of magnesium with lower risk of coronary heart disease (34-36). In addition, dietary surveys have suggested that a higher magnesium intake is associated with a lower risk of stroke (37). Further studies are needed to understand the complex relationships between dietary magnesium intake, indicators of magnesium status, and heart disease.
Magnesium and osteoporosis
Magnesium deficiency may be a risk factor for postmenopausal osteoporosis (4). This may be due to the fact that magnesium deficiency alters calcium metabolism and the hormone that regulates calcium (13). Several studies have suggested that magnesium supplementation may improve bone mineral density (4), but researchers believe that further investigation on the role of magnesium in bone metabolism and osteoporosis is needed.
Magnesium and diabetes
Magnesium is important to carbohydrate metabolism. It may influence the release and activity of insulin, the hormone that helps control blood glucose levels (15). Elevated blood glucose levels increase the loss of magnesium in the urine, which in turn lowers blood levels of magnesium [(14). This explains why low blood levels of magnesium (hypomagnesemia) are seen in poorly controlled type 1 and type 2 diabetes.
In 1992, the American Diabetes Association issued a consensus statement that concluded: "Adequate dietary magnesium intake can generally be achieved by a nutritionally balanced meal plan as recommended by the American Diabetes Association." It recommended that "... only diabetic patients at high risk of hypomagnesemia should have total serum (blood) magnesium assessed, and such levels should be repleted (replaced) only if hypomagnesemia can be demonstrated" (18).
What is the Recommended Dietary Allowance for magnesium for adults?
